Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids.We identified an sSNP that modifies the local translation speed of the cystic fibrosis transmembrane conductance regulator (CFTR), leading to detrimental changes to protein stability and functio
The article substantiates read more the need to diagnose the state of innovative development of enterprises in Kyiv.It is determined that the solution to the problems of destabilization of enterprises is seen primarily in the formation of a system of conceptual foundations for ensuring innovative development and its diagnostics.The prerequisites fo
Background: Dissociative amnesia, also referred to as psychogenic amnesia, is a type of retrograde memory loss often associated with traumatic or stressful life events.While its prevalence in the medical literature is limited and it is understood to be a rare disorder with no changes noted on imaging ilootpaperie studies, functional imaging analysi
Orientation directors are continually searching for a strong conceptual framework to undergird and improve their training of orientation leaders (OLs).Instead of developing a sophie allport zebra series of random, discrete training exercises, it is preferable that orientation practitioners structure and develop training using an established, proven
Matrix-deprivation stress leads to cell-death by anoikis, whereas overcoming anoikis is critical for cancer metastasis.Work from our lab and others has identified a crucial role for the cellular energy sensor AMPK in anoikis-resistance, highlighting a key here role for metabolic reprogramming in stress survival.Protein synthesis is a major energy-c